![]() ![]() Inspired by 1024 and Threes!, our free 2048 game is an exciting combination of math and strategy. We hope you enjoy playing our free 2048 game, and best of luck on your way to producing a tile with a value of.2048!Ģ048 is a cool math and puzzle game that was created in 2014 and quickly became popular around the globe.
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![]() ![]() The cookies is used to store the user consent for the cookies in the category "Necessary". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". ![]() The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. If you want to download more software, visit Open the “crack” or “patch” file, copy and paste it into the installation directory and run it. Then extract the RAR file and open the folder.Īctivate and deactivate settings from anywhere. The hard drive space should be about 240MB. Provides a free 150MB / day VPN for safe and private browsing. This application protects your Wi-Fi network from intruders and intrusive neighbors. It fully protects your devices from ransomware attacks.Ĭompatible with Mac, Windows, and Android devices.
![]() ![]() The Green Ember is for every age group, except babies (I know this, man. When you back the book, it makes everything easier and removes obstacles to us doing this the way we believe it should be done (illustrations, hard cover, etc). I would have to sell more books than I’m going to sell in order to make anything close minimum wage, but that’s not what it’s about. Many of you know that (almost) anyone who does this for the money is insane. You’ll be helping me launch my career as an author. But even just getting the $15 paperback copy is great! Christmas presents? Check.ĩ. Those obviously help us out a bunch and are too pricy for many. The Green Ember makes a great Christmas present. If you order through the Kickstarter, you can go ahead and take care of Christmas presents because it will all be at your house in time! If you want to give a bunch as gifts, there’s a higher tier where you can get ten extra copies along with most of the other stuff from the high tiers. “A captivating story with sword-bearing rabbits, daring quests, and moments of poignant beauty, The Green Ember is a tale that will delight and inspire young readers to courage and creativity and would make a perfect book for a family to read aloud.”Ĩ. (Do you have Read for the Heart?You should.) She knows children’s books and books for families. Sarah Clarkson said this about The Green Ember. This project pushes us further into that kind of work.ħ. We want to do things in the flesh, like conferences serving a few hundred kids in person. We love the web stuff, but we want to do things you can feel and touch in the real world, like books. We had a conference last year, Inkwell, and thanks to a great team it was an incredible success! We are firmly hooked on incarnational endeavors. Andrew Mackay, my amazing partner at Story Warren and a veteran of publishing, has been working a long time on his own publishing company. (The version with his illustrations will only be available during this Kickstarter.) My daughter also did something cool that backers will receive, though it’s not listed in the rewards. My 9 year old son illustrated a companion book available in some of the packages. The kids have been involved from day one as audience, editors, and biggest supporters, urging me on. Randall Goodgame sings with his wife and kids, Andrew Peterson has his family band, and I’ve always had a soft spot for family endeavors like that. I love his illustrations and the cover art he made. The man is a wonder and it was wonderful to partner with him on this project. Some of you met him and heard him talk at Hutchmoot. He’s an incredible illustrator and kind of a genius. We saw a lot of enthusiasm as we met our initial goal in 19 hours! It’s been a hoot.Ĥ. We had so many friends from all over eager to support the project, including some fine Rabbit Roomers. Without a celebrity name to trade on (no one’s paying to have coffee with, or get a phone call from me) and without celebrity cheerleaders (unless you count early enthusiasts Randall Goodgame and Jonathan Rogers…and I should) or much organization (outside of a few in the Story Warren team), we’ve managed to make a little dent. Made my decade!) Kickstarter has been bullish on our presentation since day one. (Including this amazing kid in Tennessee whose dad sent me a video of his excitement after he finished the book. But we’ve had great feedback from our early readers and everyone who has read it has loved it. OK, not very many people have read the book. ![]() And if that carries over a little bit outside our family, I’ll be delighted.ģ. That may not mean much, but I hope that means it’s a story shaped by real interaction with real children I love. ![]() So, it’s a tale that grew in the years of telling it to my kids. I didn’t write a rabbit story because of The Rabbit Room, or Story Warren, this story goes back long before either existed. I began the stories that eventually became The Green Ember on our porch, telling our then-toddler tales of the rabbits that dashed around our yard. It’s a story that grew out of our family life together. My dear friend Brian Patton made it and he’s the man. It has a cool part you’ll want to stay tuned for. But it’s a good video, I think, and I’m pleased with it. It’s a little long, yes, attention spans on-line being what they are (or aren’t). ![]() Why should you back The Green Ember on Kickstarter?ġ. Spurgeon’s General Warning: Thinly-disguised bragging follows and bragging cometh of pride, which is deadly. Like charismatic church services, these follow no particular order. I’m going with a gimmick that involves what Math “People” call “Numerical Collisioning.” You’ll see at the end. OK, eleventy would be too many, so let me just admit up front that the headline was designed to suck you in. ![]() ![]() ![]() ![]() Michael Ball has had a highly successful career as a singer, actor, TV and radio presenter. Michael is the proud godfather to Cathy's grandson, 11-year-old Connor. His wife Cathy McGowan has a daughter, Emma, with her first husband actor Hywell Bennett. But what do you expect? She’s Irish and I’m in musical theatre!" Now we both say exactly what’s on our minds. "When you have so much shared history with someone, there’s a lovely comfort to that, although the mad rush of youth is terrific." Grammy-winning singer-songwriter Michael McDonald reflects his early days playing banjo with his dad, and why hes still proud to be a Doobie Brother. "There’s something about the security and warmth of knowing that one person who, whatever happens, will always be on your side. ![]() Speaking about their relationship to the Daily Mail in 2013, Michael said: Who is Captain Tom Moore's daughter Hannah-Ingram Moore? His 1987 album Faith won a Grammy for best album of the year. In a shocking turn of events, she saved Michael's life by dragging him out of a house fire at their home in 2000. Grammy Award-winning singer George Michael was one of the leading pop stars of the 1980s and 1990s. The pair have been together since 1992, but met in 1989 when Cathy was working as an entertainment reporter at the BBC and interviewed him regarding his musical Aspects Of Love.Ĭathy McGowan And Michael Ball pictured in the early '90s.Ĭathy was hugely famous in the 1960s as the presenter of TV show Ready, Steady, Go! but made the conscious decision to walk away from public life. Watch Captain Tom Moore appear on Blankety Blank as a contestant With his warm voice and cool moves, his sultry sound and swinging songs, Michael Doubl proves time and again to bring complete and professionally taken care of. and German pianist (1889-1984) famous as an accompanist to many great singers. Michael Ball is in a long-term relationship with Cathy McGowan, 79, but have never married. Ivogun, Maria - Raucheisen, Michael - Double Signed Photo 1974 - Tamino. Michael Ball returns as Javert in Les Misérables 35 years on ![]() ![]() ![]() Who will be the master of the track in your house? Up to four people can play at one time, making this a perfect family co-op game. Use super simple controls to speed your colorful racing car over 130 different levels that include racing through the desert, hot lava, and the sky! What’s more, there’s a level editor you can use to make your own, unique racing tracks for even more fun. This dynamic racing game will either bring up childhood memories in adults or help kids create their own. Platform: Nintendo Switch, PS4, Xbox One, PC As usual, the game is full of boss battles and neat locations and the co-op option lets the first player play as Sonic while the second one plays as one of Sonic’s trusted friends, helping him win over bosses and collect points. ![]() Rated: ESRB Everyone Sonic Mania Source: Sonic Mania Press kitĪdults and parents might get a little teary-eyed at the retro look of a franchise they probably remember from their childhood. Platform: PC, PS4 and 5, Xbox One, Nintendo Switch It’s most fun when you gather your family and play as a team or play against each other to see who the best (and wackiest) player is. What’s better than playing a fun game of soccer? Playing it as a futuristic car, of course! Toss around a huge soccer ball while trying to outwit your rivals and score a goal. Rocket League Source: Rocket League Press kit Rated: PEGI 12 Get the game for your platform: Launch local co-op mode and grab a family member and make them your wingman (or woman!) or join versus mode and try to take each other down. Upgrade your pilot skill tree and choose from multiple plane skins to make your dogfights even more fun. Red Wings: Aces of the Sky is an arcade action game that puts you in the cockpit of a WWI fighter plane. If your children keep stealing your aviator sunglasses and run around making airplane noises, this is the perfect game for them. ![]() Rated: ESRB Everyone Red Wings: Aces of the Sky Be careful though, if one blob dies, the other fizzles away and you both need to start the level over. You play as either a pink or green blob, and you have to work together to make it through each puzzle platform level so this is a great choice to get siblings to work together. The controls are easy to master (the only options are to walk and jump), making it a game you can pick and start playing in a matter of minutes. This rather unknown indie title is challenging in its simplicity. Rated: ESRB Everyone Get the game for your platform: This is one of the best family co-op games because not only does it offer hours of crazy fun, it also teaches the power of teamwork (and organization). Join up to three players to paint walls, move couches, and clean up the trash according to the supplied blueprint before the clock runs out. This intensely fun local co-op game will challenge your interior design skills with multiple levels, renovation tasks, and things that can go terribly (and hilariously) wrong. Best of all, all of these games are kid-friendly, but adults will have a blast as well! Tools Up! There are options for everyone from puzzle lovers to racing enthusiasts as well as families both big and small. We’re sure that you’ll find something there to bring back a bright smile to your kid’s face, no matter their age. They whine, they complain, and they basically make you pray for school to start sooner than usual.īut before you go calling up the principal, take a look at our best family co-op games. The next worst thing to a rainy summer is a summer with a delightful bunch of bored kids. ![]() ![]() ![]() Added parameter change when transferring character from ATOM RPG ġ7. Blaze's quest fixed (not Brothers Samuil, they will be added a bit later) ġ6. Characters stuck in furniture when trying to get to closets fixed ġ3. Greetings from Solntsegrad quest fixed ġ0. Random encounters do not refresh after walking out ĩ. Aspic fights rebalanced, errors with fighting through terrain fixed Ħ. ![]() "Meeting with creator" encounter fixed ģ. Fixed tavern loading zone for transferred characters Ģ. Thank you for your understanding, and now we are returning back to the developmentġ. In case it's not, don't hesitate to write to us! If you encountered a bug in the previous version of the game, please consult this list: Maybe it was already resolved. The game features topics of drug, tobacco and alcohol abuse as well as some mature language and sexual themes. The game has graphic violence (blood and partial dismemberment). The developers describe the content like this: We really hope you will enjoy Atom RPG: Trudograd! This game encompasses a lot of changes from our previous title, that were inspired by user feedback.
![]() The game depends far too heavily on luck, important information is not readily available to the player, the controls are atrocious, and the game repeatedly crashes. Tl dr - Merchants of Kaidan is a "buy low"/"sell high" Trading Simulation game with a good presentation but that fails in pretty much every other area. It's a shoddy port of a game that relies far too heavily on luck, doesn't properly convey important information to players, has terrible interface issues, and just overall is not fun to play. I'm sure that those who can stick with it despite its many, many flaws will find some fun to be had in Merchants of Kaidan, but I personally cannot remember the last time I was this disappointed in a game. I mean, not enough to justify all the crashing this game is doing, but they're nice. I swear, I went into this game actually excited to play a good trading sim, and it seemed to want to do everything it could to make me absolutely hate it.Īt the very least, the game's visuals and music are pleasant enough. ![]() Thankfully, you can use the touchscreen for menus in handheld mode, but it's frustrating that this should even be necessary just to not have to be tortured by the tedium of selecting choices in menus.Īs if this wasn't bad enough, during my time playing this game, it outright crashed on me multiple times. This game wasn't made for consoles, and it shows. At multiple points, I was approached by someone who wanted to be taken to a specific place, but I wasn't given a chance to check my map before agreeing or refusing, and couldn't locate the place on the map afterward - there certainly wasn't anything highlighting the place or denoting it as a destination.Įven if you're fine with all of this oppressive difficulty and poor luck, and lack of helpful information, the game still makes playing it a frustrating chore, with menus that have you dragging a slow cursor across the screen instead of simply snapping to the options you can click on. and even if you find something that works well for you, misfortune could always strike anyway.Īlso, much of the information that you need is either nestled away in menus, or not available to you at all, and none of it is presented in a helpful or user-friendly manner. The costly business of simply getting from one place to another can lead to slim margins, and you're discouraged from exploiting a good route because it could lead to robbers attacking you. It doesn't help that the game is difficult enough as-is. whenever one of these events happens, it's always frustrating. Encouraged to bet on a race? Refuse and you may suffer unintended consequences from disheartened staff. ![]() A woman with empty buckets passes in front of your cart? Your luck stat goes down. Firstly, there are a lot of events in this game that are completely out of your control. In addition, you'll be investing in businesses, encountering events that can change your luck, and taking on quests that can help increase your fortune and status.Īll of this sounds good, but the game is plagued by problems. ![]() Here, you'll start by trading in just two resources, food and furs, and gradually move on to others as your status rises. Merchants of Kaidan is a Trading Simulation game with a focus on arbitrage, the practice of buying low in one location and selling high in another to turn a profit - compare this to games like Star Trader, Trade Wars, and Dope Wars, to give you an idea what you're in for. ![]() ![]() ![]() They performed the experiment by forcing cells to make unnatural quantities of two proteins: LINEs and HIV reverse transcriptase (RT). Then they infected these cells with the SARS-CoV-2 virus, and reported that the SARS-CoV-2 viral RNA is converted into DNA. To prove their claims in an experimental setup, the authors genetically altered cells to make proteins that can perform reverse transcription. So the chimeric viral and human RNA could just be an artefact of the RNA-seq process, since reverse transcriptases are known to mix and match target sequences. The authors appear to have overlooked the fact that in the process of preparing a sample for RNA-seq, the scientist must herself artificially reverse transcribe RNA into DNA – because only DNA can be sequenced (for further study). This data may seem convincing at first glance, but the devil is in the details. The authors reported that in cells infected with SARS-CoV-2, there were some viral RNA sequences interspersed between RNA sequences of human genes. So a RNA-seq’s output is a sort of measure of all the genes that are active in the target cell. The observation banks on a powerful tool called RNA-seq, which provides the sequences of all the RNA molecules produced by a cell. The authors’ claims are based largely on one primary observation and one experiment. This process differs from what retroviruses like HIV do routinely: they use their own proteins to convert and mix the DNA. The paper claims these LINEs do the same thing with parts of the novel coronavirus’s RNA as well. The human genome has multiple LINEs – effectively, parts of our DNA responsible for reverse-transcribing human RNA into DNA, and integrating it into the human DNA at a different part. Their explanation is based on a group of genetic entities called long interspersed nuclear elements (LINE). The paper claimed, outlandishly, that parts of the SARS-CoV-2 viral RNA could be reverse transcribed into DNA and integrated into the human genome.Īccording to the paper’s authors, they were attempting to explain why some COVID-19 patients showed signs of the virus in RT-PCR tests even weeks after recovering from the disease. This is why a preprint paper uploaded to the bioRxiv preprint server on December 13 caught the scientific community by surprise. It’s also unusual – maybe even impossible – to have members of one class of viruses show fundamental properties associated with another.Īlso read: Why Is It so Difficult to Fight HIV? In all, there are seven families, or groups, of viruses, and each group specifies special adaptations, refined over years of evolution, often through several hosts. Viruses like HIV and Rous sarcoma belong to this family. Such viruses – called retroviruses – violate the central dogma because information first flows from RNA to DNA, and then from the DNA to the RNA to proteins. A virus then mixes this DNA with the DNA of its host, thus becoming part of the host forever. They found viruses that could make a DNA copy with their RNA using an enzyme called reverse transcriptase, in a process called reverse transcription. These viruses also deviate from the central dogma only slightly: there is no DNA, but the information flows only from the RNA to proteins.īut what Temin and Baltimore discovered in 1970 was a proper exception to the central dogma. ![]() The influenza, hepatitis C and SARS-CoV-2 viruses are in this category. Some viruses contain the machinery to make copies of their RNA, and they don’t have a DNA component in their life cycle whatsoever. To propagate itself, each virus makes a copy of the information in its genetic material to pass onto its ‘daughter’ viruses. There are different kinds of RNA-containing viruses. Viruses are the only known life-forms that can use RNA as their genetic material. This is because they can be both alive and not alive – a feature that demands that taxonomists also consider other attributes that make viruses different.Īnother such feature is their genetic material. However, viruses are not classified the same way as other life forms. Viruses, like other living beings, come in all shapes and sizes, and are classified into different families. In this year, Howard Temin and David Baltimore found something odd in one group of viruses. And everywhere scientists looked, they realised all organisms followed this dogma – until 1970. He suggested that information always flows in living beings from DNA – a stable, inheritable molecule – through a relatively unstable intermediate, the messenger RNA, and then onto proteins, which are the workhorses of all life functions. In September 1957, Francis Crick proposed the ‘central dogma of molecular biology’. ![]() ![]() ![]() ![]() Site Master comes with OSL, InstaCal™, and FlexCal™įeatures: Superior immunity to RF interference, locate long range problems with 517 data points, saves up to 25 measurement test set-ups, saves up to 2000 measurement traces.Įach Unit Includes: Site Master User Guide, Soft Carrying Case, MST CD: Master Software Tools, User/ Measurement Guides, Programming Manual, Troubleshooting Guides, Application Notes, Rechargeable Li- Ion Battery, AC-DC Adapter, Automotive Cigarette Lighter 12 VDC Adapter, USB A/5-pin Mini-B Cable-10ft. Site Master automatically calculates the average cable loss.ĭistance-to-fault (DTF) is used to troubleshoot systems and locate the problem. ![]() Use the Site Master to make return loss and VSWR and verify that the cable and antenna system conforms to performance specifications Accuracy: > 42 dB corrected directivity Display: TFT color with adjustable backlight Calibration: OSL, InstaCal. Will the InstaCal Calibration Module, ICN50, work on the MS2036A answer. The Anritsu Site Master S331L is an all inclusive 1-port cable and antenna analyser covering the 2 MHz to 4 GHz range, with a built-in InstaCal module and a. Degraded cable systems and badly positioned antennas affect overall system coverage and eventually result in dropped calls. The majority of the problems you find at a typical cell site are caused by problematic cables, pinched cables, corroded connectors, antennas, lightning strikes, rain getting into cables, and bullet holes. Unlike a discrete calibration compo- nent, the InstaCal module can not be used at the top of the tower to conduct load or inser- tion loss measurements. It is suited for any experience level user for installing, commissioning, troubleshooting and maintaining today's wireless systems. The ICN50 InstaCal module provides field users with a convenient and fast way to perform the calibration as it eliminates the need to change the connection. Site Master S361E, covering 2MHz to 6GHz is designed to accurately locate and identify RF cable feed-line and antenna system faults. ![]() ![]() ![]() (DAWN) jumped 21 in premarket trading on Monday after the company shared positive data from an ongoing. Day One Biopharmaceuticals is a clinical-stage biopharmaceutical company dedicated to developing and commercializing targeted therapies for patients of all ages with genomically-defined. The biotech is focused on new treatments, rather than repurposing adult cancer drugs with heavy side effects. MARKET PULSE Shares of Day One Pharmaceuticals Inc. Day One said “most children with pLGG survive their cancer,” but if they don’t go into remission after surgery, they might have to undergo aggressive therapies for years.ĭay One went public in 2021 on the narrative that many drug developers de-emphasized pediatric cancer patients in their clinical development. Headquarters 395 Oyster Point Blvd Ste 217, South San Francisco, California, 94080, United States Phone Number (650) 484-0899 Website Revenue 11.6M Stock Symbol DAWN Industry Business Services General Business Services Day One Biopharmaceuticals, Inc. The biotech said there are no current treatments approved for pLGG. “We look forward to continuing our discussions with regulatory authorities with the hope of bringing this therapy to children in need of new options as soon as possible,” Bender said. Upcoming data from all patients in the trial will be included in the NDA filing, CEO Jeremy Bender said in a statement. Other side effects included an increase in creatine phosphokinase, anemia, fatigue and maculopapular rash.ĭay One will submit more data to present at a medical meeting next quarter. The California biotech said the drug was “generally well-tolerated,” with change in hair color being the most common side effect as seen in 75% of 77 treated patients. Three patients fully responded to the treatment while 41 benefited partially, 10 of which were unconfirmed, Day One said this weekend. It does not store any personal data.With pan-RAF drug from Takeda, Day One unveils its first pediatric brain cancer data. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. Other languages Press Releases Official Publications Sector news DAY ONE BIOPHARMACEUTICALS, INC. The cookie is used to store the user consent for the cookies in the category "Performance". 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40431 DAY ONE BIOPHARMACEUTICALS, INC. (DAWN) Add to my list Report Summary Quotes Charts News Ratings Calendar Company Financials Consensus Revisions Funds Summary Most relevant All News Analyst Reco. This cookie is set by GDPR Cookie Consent plugin. Day One Biopharmaceuticals, a clinical-stage biopharmaceutical company dedicated to developing and commercializing targeted therapies for people of all ages. 27, 2023 (GLOBE NEWSWIRE) - Day One Biopharmaceuticals (Nasdaq: DAWN), a clinical-stage biopharmaceutical company dedicated to developing and commercializing. The cookie is used to store the user consent for the cookies in the category "Other. This cookie is set by GDPR Cookie Consent plugin. Day One Biopharmaceuticals Jan 2021 - Present2 years 3 months San Francisco Bay Area Overseeing Regulatory Science, Clinical Operations, Biometrics, Program Management, Product Leadership and. The cookies is used to store the user consent for the cookies in the category "Necessary". ![]() This cookie is set by GDPR Cookie Consent plugin. FIREFLY-1, FIREFLY-2 and FIRELIGHT-1 Clinical Trials are. ![]() The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". Day One develops new medicines for people of all ages living with life-threatening diseases. The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. ![]() |